Diagnostics and Prognostication of Myelodysplastic Syndromes
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چکیده
منابع مشابه
Diagnostics and Prognostication of Myelodysplastic Syndromes
MDS are a heterogeneous and complex group of clonal hematological neoplasms arising from a hematopoietic stem cell, and characterized by ineffective hematopoiesis, resulting in increased apoptosis in the bone marrow and peripheral cytopenia, which involves one or more lineages. Epigenetic changes are reported as 'founder' mutations in the case of MDS. Its incidence in the general population has...
متن کاملPerspectives in the prognostication of myelodysplastic syndromes.
Since the first precise definition of myelodysplastic syndromes (MDS) in 1982, prognostication of this disease has been a matter of debate. It very quickly became clear that the prognosis of MDS patients cannot be assessed by a single parameter, although the prognostic impact of the FAB classification, which is based on bone marrow morphology, is still impressive. This reflects the fact that th...
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Etiology of myelodysplastic syndromes The models for the development of sporadic MDS suggest the role of cumulative environmental exposures in genetically predisposed individuals. There is increasing evidence for a complex genetic predisposition to MDS involving naturally occurring DNA polymorphisms in genes that mediate DNA repair and metabolize environmental carcinogens.3 Large epidemiologic ...
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The myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders characterized by dysplastic and ineffective hematopoiesis and a varying risk of transformation to acute leukemia. Although the natural history of these syndromes is variable, several factors appear to be of prognostic importance, including the French-American-British classification, the karyotype, in vi...
متن کاملMyelodysplastic syndromes.
These two issues of the Seminars in Hematology will provide the physician the necessary knowledge to help make sense of this somewhat confusing array of diseases. The subdivisions of MDS reflect the precision of our techniques of dissection, with morphological and histochemical analyses forming the foundation to identify and subdivide MDS. Although steady refinement has occurred over the last h...
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ژورنال
عنوان ژورنال: Annals of Laboratory Medicine
سال: 2017
ISSN: 2234-3806,2234-3814
DOI: 10.3343/alm.2017.37.6.465